供应批发Recombinant Murine IL-12 Peprotech细胞因子价格

 

 

Catalog Number:

210-12

 

 

Synonyms:

NKSF, CTL maturation factor （TCMF）, Cytotoxic lymphocyte maturation factor （CLMF）, TSF

 

 

Description:

IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant murine IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa （p35） and 40 kDa （p40） subunits （506 total amino acid residues）.

 

 

AA Sequence:

p35 Subunit: RVIPVSG PARCLSQSRN LLKTTDDMVK TAREKLKHYS CTAEDIDHED ITRDQTSTLK TCLPLELHKN ESCLATRETS STTRGSCLPP QKTSLMMTLC LGSIYEDLKM YQTEFQAINA ALQNHNHQQI ILDKGMLVAI DELMQSLNHN GETLRQKPPV GEADPYRVKM KLCILLHAFS TRVVTINRVM GYLSSA

 

 

p40 Subunit: MWELEKD VYVVEVDWTP DAPGETVNLT CDTPEEDDIT WTSDQRHGVI GSGKTLTITV KEFLDAGQYT CHKGGETLSH SHLLLHKKEN GIWSTEILKN FKNKTFLKCE APNYSGRFTC SWLVQRNMDL KFNIKSSSSS PDSRAVTCGM ASLSAEKVTL DQRDYEKYSV SCQEDVTCPT AEETLPIELA LEARQQNKYE NYSTSFFIRD IIKPDPPKNL QMKPLKNSQV EVSWEYPDSW STPHSYFSLK FFVRIQRKKE KMKETEEGCN QKGAFLVEKT STEVQCKGGN VCVQAQDRYY NSSCSKWACV PCRVRS

 

 

Source:

CHO cells

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

 

 

Biological Activity:

Assay #1: The ED ₅₀ was determined by the stimulation of IFN-gamma production by murine splenocytes co-stimulated with IL-18 is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 10 ⁷ units/mg.
Assay #2: Determined by its ability to stimulate the proliferation of 2D6 cells. The expected ED ₅₀ is ≤0.1ng/ml, corresponding to a specific activity of ≥1 x 10 ⁷ units/mg.

 

 

Cross Reactivity:

Human, Mouse, N/A, Cow + Mouse

 

 

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